TOLERANCE SHOWN BY Rattus rattus TO AN ANTICOAGULANT RODENTICIDE

Apart from u s i n g 0.005% concentration, the recommended f i e l d dose of 0.025% of the anticoagulant is used along w i t h an alternate food for i n d i v i d u a l rats for a varying number of days. Those that had survived were taken as tolerant, provided they showed an mg/kg intake beyond the tolerance l i m i t , survived a s i x days of feeding, e x h i b i t e d b a i t shyness and d i d not e x h i b i t hemorrhage after death. In determining the c r i t e r i a for tolerance to an anticoagulant by a rat, one s h o u l d take into account four composite factors. These are, s i x days of even 0.025% feeding, b a i t shyness when alternate food is g i v e n , h i g h e r mg/kg intake than the tolerance level and a l o s s of i n t e n s i v e hemorrhage after death.